Short-term effect of low-dose colchicine on inflammatory biomarkers, lipids, blood count and renal function in chronic coronary artery disease and elevated high-sensitivity C-reactive protein.
Aernoud T L FioletMax J M SilvisTjerk S J OpstalWillem A BaxFrans A L van der HorstArend MosterdDominique de KleijnJan H CornelPublished in: PloS one (2020)
In patients with chronic coronary artery disease and elevated hs-CRP, one-month exposure to colchicine 0.5 mg once daily was associated with a reduction of inflammatory markers. A small effect was seen on white blood cell count and platelet count, as well as a small decrease in estimated glomerular filtration rate.
Keyphrases
- coronary artery disease
- low dose
- peripheral blood
- percutaneous coronary intervention
- coronary artery bypass grafting
- cardiovascular events
- single cell
- oxidative stress
- cell therapy
- physical activity
- type diabetes
- stem cells
- fatty acid
- mesenchymal stem cells
- atrial fibrillation
- aortic stenosis
- ejection fraction
- drug induced