Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes.
Jonathan P BradfieldRachel L KemberAnna UlrichZhanna BalkiyarovaAkram AlyassIzzuddin M ArisJoshua A BellK Alaine BroadawayZhanghua ChenJin-Fang ChaiNeil M DaviesDietmar Fernandez-OrthMariona BustamanteRuby ForeAmitavo GanguliAnni HeiskalaJouke-Jan HottengaCarmen ÍñiguezSayuko KobesJaakko LeinonenEstelle LowryLeo-Pekka LyytikainenAnubha MahajanNiina PitkänenTheresia M SchnurrChristian Theil HaveDavid P StrachanElisabeth ThieringSuzanne VogelezangKaitlin H WadeCarol A WangAndrew WongLouise Aas HolmAlessandra ChesiCatherine ChoongMiguel CruzPaul ElliottSteve FranksChristine Frithioff-BøjsøeW James GaudermanJoseph T GlessnerVicente GilsanzKendra GriesmanRobert L HansonMarika KaakinenHeidi KalkwarfAndrea KellyJoseph KindlerMika KähönenCarla LancaJoan LappeNanette R LeeShana McCormackFrank D MentchJonathan A MitchellNina MononenHarri NiinikoskiEmily OkenKatja PahkalaXueling SimYik-Ying TeoLeslie J BaierToos van BeijsterveldtLinda S AdairDorret I BoomsmaEco de GeusMònica GuxensJohan G ErikssonJanine F FelixFrank D GillilandPenn Medicine BiobankTorben HansenRebecca HardyMarie-France HivertJens-Christian HolmVincent W V JaddoeMarjo-Riitta JärvelinTerho LehtimäkiDavid A MackeyDavid MeyreKaren L MohlkeJuha MykkänenSharon OberfieldCraig E PennellJohn R B PerryOlli RaitakariFernando RivadeneiraSeang-Mei SawSylvain SebertJohn A ShepherdMarie StandlThorkild I A SørensenNicholas J TimpsonMaties TorrentGonneke WillemsenElina HypponenChris Powernull nullMark I McCarthyRachel M FreathyElisabeth WidénHakon HakonarsonInga ProkopenkoBenjamin F VoightBabette S ZemelStruan F A GrantDiana L CousminerPublished in: Genome biology (2024)
We report novel genetic associations with the tempo of pubertal growth and find that genetic determinants of growth are correlated with reproductive, glycemic, respiratory, and cardiac traits in adulthood. These results aid in identifying specific growth trajectories impacting lifelong health and show that there may not be a single "optimal" pubertal growth pattern.