Associations between Personal PM2.5 Elemental Constituents and Decline of Kidney Function in Older Individuals: the China BAPE Study.
Jianlong FangSong TangJingwen ZhouJingyang ZhouLiangliang CuiFanling KongYing GaoYu ShenFuchang DengYingjian ZhangYuanyuan LiuHaoran DongXiaoyan DongLi DongXiumiao PengMeng CaoYan WangChangming DingYanjun DuQiong WangChong WangYi ZhangYanwen WangTiantian LiXiaoming ShiPublished in: Environmental science & technology (2020)
Long-term exposure to fine particulate matter (PM2.5) is associated with kidney dysfunction. However, few studies have investigated acute effects of PM2.5 elemental constituents on renal function. We evaluated associations between personal PM2.5 and its elemental constituents and kidney function, assessed by an estimated glomerular filtration rate (eGFR) in Biomarkers of Air Pollutants Exposure in the Chinese aged 60-69 study. Seventy one older individuals were visited monthly between September 2018 and January 2019. Each participant wore a PM2.5 monitor for 72 h, responded to a questionnaire, and underwent a physical examination with blood sampling. Linear mixed-effect models were used to estimate associations between personal PM2.5 elemental constituents and eGFR. We found that significant changes in eGFR from -1.69% [95% confidence interval (CI): -3.34%, -0.01%] to -3.27% (95% CI: -5.04%, -1.47%) were associated with interquartile range (IQR) increases in individual PM2.5 exposures at various lag periods (7-12, 13-24, 0-24, 25-48, and 49-72 h). An IQR increase in 72 h moving averages of copper, manganese, and titanium in personal PM2.5 corresponded to -2.34% (95% CI: -3.67%, -0.99%) to -4.56% (95% CI: -7.04%, -2.00%) changes in eGFR. Personal PM2.5 and some of its elemental constituents are inversely associated with eGFR in older individuals.
Keyphrases
- particulate matter
- air pollution
- small cell lung cancer
- epidermal growth factor receptor
- polycyclic aromatic hydrocarbons
- tyrosine kinase
- heavy metals
- physical activity
- water soluble
- intensive care unit
- mental health
- community dwelling
- essential oil
- liver failure
- high resolution
- hepatitis b virus
- cross sectional
- case control