Epigenetic down-regulation of SOX2 is an independent poor prognostic factor for hypopharyngeal cancers.

Mehmet Özgür AvinçsalNaoe JimboKohei Fujikura Hirotaka ShinomiyaNaoki OtsukiKoichi MorimotoTatsuya FurukawaNaruhiko MoritaRitsuko MaeharaTomoo ItohKen-Ichi NibuYoh Zen

Published in: Histopathology (2018)

Similarly to oesophageal cancers, a small subset (8%) of HPSCCs characteristically almost completely lacking SOX2 expression appeared to be aggressive neoplasms with high recurrence rates. Promoter hypermethylation was determined to be a major mechanism underlying epigenetic SOX2 silencing.

Keyphrases

transcription factor
prognostic factors
dna methylation
stem cells
gene expression
poor prognosis