Reduced interleukin-18 secretion by human monocytic cells in response to infections with hyper-virulent Streptococcus pyogenes.
Lea A TölkenAntje D PaulikatLana H JachmannAlexander RederManuela Gesell SalazarLaura M Palma MedinaStephan MichalikUwe VölkerMattias SvenssonAnna Norrby-TeglundKatharina J HoffMichael LammersNikolai SiemensPublished in: Journal of biomedical science (2024)
Our data demonstrate that strains, which harbor covR/S mutations, interfere with IL-18 and IL-8 responses in monocytic cells by utilizing the caspase-8 axis. Future experiments aim to identify the underlying mechanism and consequences for NSTI patients.
Keyphrases
- induced apoptosis
- cell cycle arrest
- end stage renal disease
- endoplasmic reticulum stress
- endothelial cells
- newly diagnosed
- cell death
- ejection fraction
- escherichia coli
- oxidative stress
- chronic kidney disease
- peritoneal dialysis
- signaling pathway
- electronic health record
- big data
- patient reported outcomes
- candida albicans
- cystic fibrosis
- cell proliferation
- induced pluripotent stem cells
- pluripotent stem cells
- deep learning
- artificial intelligence