A scalable algorithm for structure identification of complex gene regulatory network from temporal expression data.

Shupeng GuiAndrew P RiceRui ChenLiang WuJi LiuHongyu Miao

Published in: BMC bioinformatics (2017)

The proposed algorithm is the first scalable method for large complex network structure identification. The GRN structure identified by our algorithm could reveal possible biological links and help researchers to choose which gene functions to investigate in a biological event. The algorithm described in this article is implemented in MATLAB Ⓡ , and the source code is freely available from https://github.com/Hongyu-Miao/DMI.git .

Keyphrases

machine learning
deep learning
genome wide
neural network
poor prognosis
big data
artificial intelligence
copy number
gene expression
dna methylation
single cell
transcription factor