TC2N inhibits distant metastasis and stemness of breast cancer via blocking fatty acid synthesis.

Xiang-Lin HaoYang-Fan LvDe-Feng LiFu-Hai BaiJi GongGuang-Qiang PanLin-Xi SuYa-Li WangWan-Lei FuBo LiuLu HuangDong YanQiu-Lin TanJin-Yi LiuQiao-Nan Guo

Published in: Journal of translational medicine (2024)

Altogether, we demonstrate a previously unidentified role and mechanism of TC2N in regulation of lipid metabolism and PTEN neddylation, providing a potential therapeutic target for anti-cancer.

Keyphrases

fatty acid
stem cells
epithelial mesenchymal transition
cell proliferation
lymph node
pi k akt
human health
risk assessment
cancer stem cells
childhood cancer