The carboxy terminus of yeast Atg13 binds phospholipid membrane via motifs that overlap with the Vac8-interacting domain.

Damián GaticaAlejandro DamasioClarence Pascual Daniel J Klionsky Michael J RagusaHana Popelka

Published in: Autophagy (2019)

Atg: autophagy-related; CD: circular dichroism; Cvt: cytoplasm-to-vacuole targeting; IDR: intrinsically disordered region; ITC: isothermal calorimetry; MIM: MIT-interacting motif; MKO: multiple-knockout; PAS: phagophore assembly site; PC: phosphatidylcholine; PS: phosphatidylserine; PtdIns: phosphatidylinositol; PtdIns3P: phosphatidylinositol-3-phosphate.

Keyphrases

protein kinase
cell death
endoplasmic reticulum stress
signaling pathway
oxidative stress
cancer therapy
fatty acid
saccharomyces cerevisiae
cell wall