Impact of mineralocorticoid receptor antagonist in renal transplant patients: a systematic review and meta-analysis of randomized controlled trials.

Although an improvement in serum creatinine and urinary Hsp72 and 8-OHdG, as an expression of renoprotection induced by MR antagonists, was observed in kidney transplanted recipients, the different designs of the 4 studies limit the meaningful of this conclusion. Thus, more powered RCTs are warranted.