The Metabolic Impact of Nonalcoholic Fatty Liver Disease on Cognitive Dysfunction: A Comprehensive Clinical and Pathophysiological Review.
Mauro GiuffréNicola MerliMaura PugliattiRita MorettiPublished in: International journal of molecular sciences (2024)
Nonalcoholic fatty liver disease (NAFLD) exponentially affects the global healthcare burden, and it is currently gaining increasing interest in relation to its potential impact on central nervous system (CNS) diseases, especially concerning cognitive deterioration and dementias. Overall, scientific research nowadays extends to different levels, exploring NAFLD's putative proinflammatory mechanism of such dysmetabolic conditions, spreading out from the liver to a multisystemic involvement. The aim of this review is to analyze the most recent scientific literature on cognitive involvement in NAFLD, as well as understand its underlying potential background processes, i.e., neuroinflammation, the role of microbiota in the brain-liver-gut axis, hyperammonemia neurotoxicity, insulin resistance, free fatty acids, and vitamins.
Keyphrases
- healthcare
- insulin resistance
- fatty acid
- systematic review
- traumatic brain injury
- metabolic syndrome
- adipose tissue
- liver fibrosis
- resting state
- lipopolysaccharide induced
- white matter
- high fat diet
- risk factors
- polycystic ovary syndrome
- multiple sclerosis
- lps induced
- functional connectivity
- health information
- glycemic control
- subarachnoid hemorrhage