Spatial Gene-Expression Profiling Unveils Immuno-oncogenic Programs of NF1-Associated Peripheral Nerve Sheath Tumor Progression.
Dana K MitchellBreanne BurgessEmily E WhiteAbbi Elise SmithElizabeth A Sierra PotchanantHenry Elmer MangBrooke E HickeyQingbo LuShaomin QianWaylan BesslerXiaohong LiLi JiangKylee BrewsterConstance J TemmAndrew E HorvaiEric A AlbrightMelissa L FishelChristine A PratilasSteven P AngusD Wade ClappSteven D RhodesPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
If validated prospectively in future studies, these signatures may serve as molecular diagnostic tools to augment conventional histopathologic diagnosis by identifying neurofibromas at high risk of undergoing malignant transformation, facilitating risk-adapted care.
Keyphrases
- peripheral nerve
- gene expression
- healthcare
- dna methylation
- signaling pathway
- palliative care
- poor prognosis
- lps induced
- public health
- quality improvement
- genome wide
- current status
- single cell
- oxidative stress
- pi k akt
- case control
- pain management
- single molecule
- immune response
- affordable care act
- inflammatory response