Postoperative radiotherapy provides better local control and long-term outcome in selective cases of cutaneous squamous cell carcinoma with perineural invasion.
Javier CañuetoA JakaL A CorcheteA Mª González-PérezR García-CastroMª J FuenteI MembriveÁ MarchA MañesR PosadaR M PujolC Román-CurtoAgustín TollPublished in: Journal of the European Academy of Dermatology and Venereology : JEADV (2019)
The use of PORT on patients with CSCC with PNI and positive margins after surgery, especially in PNI ≥0.1 mm, significantly improves long-term outcome. The benefit of PORT in cases with clear margins is not as evident, especially in those with PNI of small-calibre nerves. Clinical trials are imperative.