Orthotopic model of lung cancer: isolation of bone micro-metastases after tumor escape from Osimertinib treatment.
Ulrich JarryMégane BostoënRaphaël PineauLaura ChaillotValentine MennessierPierre MontagneEmilie MotteMarjorie GournayArnaud Le GoffThierry GuillaudeuxRémy PedeuxPublished in: BMC cancer (2021)
We describe an orthotopic model of NSCLC protocol that led to lung primary tumor nesting and, after osimertinib treatment, by metastases dissemination, and that allow the isolation of these small osimertinib-resistant micro-metastases. This model provides new biological tools to study tumor progression from the establishment of a lung tumor to the generation of drug-resistant micro-metastases, mimicking the natural course of the disease in human NSCLC patients.
Keyphrases
- small cell lung cancer
- drug resistant
- advanced non small cell lung cancer
- epidermal growth factor receptor
- multidrug resistant
- end stage renal disease
- ejection fraction
- randomized controlled trial
- endothelial cells
- newly diagnosed
- chronic kidney disease
- prognostic factors
- brain metastases
- tyrosine kinase
- body composition
- smoking cessation
- postmenopausal women