P. aeruginosa tRNA-fMet halves secreted in outer membrane vesicles suppress lung inflammation in Cystic Fibrosis.

Zhongyou LiRoxanna BarnabyAmanda NymonCarolyn RocheKatja KoeppenAlix AshareDeborah A HoganScott A GerberDouglas J TaatjesThomas H HamptonBruce A Stanton

Published in: bioRxiv : the preprint server for biology (2024)

. 5' tRNA-fMet halves are delivered into host cells after OMVs fuse with lipid rafts in CF-HBEC and down-regulate protein expression of MAPK10, IKBKG, and EP300, which suppresses IL-8 secretion and neutrophils in the lungs. A reduction in neutrophils in CF BALF is predicted to improve lung function and decrease lung damage.

Keyphrases

cystic fibrosis
lung function
oxidative stress
induced apoptosis
pseudomonas aeruginosa
signaling pathway
cell cycle arrest
chronic obstructive pulmonary disease
fatty acid
cell death
endoplasmic reticulum stress