Low plasma vitamin D is associated with adverse colorectal cancer survival after surgical resection, independent of systemic inflammatory response.
Peter G Vaughan-ShawL ZgagaL Y OoiE TheodoratouM TimofeevaV SvintiM WalkerF O'SullivanA EwingS JohnstonF V N DinH CampbellS M FarringtonM G DunlopPublished in: Gut (2019)
CRC surgery induces a fall in circulating 25OHD. Plasma 25OHD level is a prognostic biomarker with low 25OHD associated with poorer survival, particularly in those with rs11568820 GG genotype. A randomised trial of vitamin D supplementation after CRC surgery has compelling rationale.