Login / Signup

ACT-Discover: identifying karyotype heterogeneity in pancreatic cancer evolution using ctDNA.

Ariana HuebnerJames R M BlackFrancesca SarnoRoberto PazoIgnacio JuezLaura MedinaRocio Garcia-CarboneroCarmen GuillénJaime FeliúCarolina AlonsoCarlota ArenillasAna Belén Moreno-CárdenasHelena VerdaguerTeresa MacarullaManuel HidalgoNicholas McGranahanRodrigo A Toledo
Published in: Genome medicine (2023)
This work demonstrates the power of haplotype phasing to study genomic variation in cfDNA samples and reveals undiscovered intra-tumour heterogeneity with important scientific and clinical implications. Implementation of ACT-Discover could lead to important insights from existing cohorts or underpin future prospective studies seeking to characterise the landscape of tumour evolution through liquid biopsy.
Keyphrases
  • single cell
  • primary care
  • healthcare
  • mental health
  • ionic liquid
  • ultrasound guided
  • case control
  • fine needle aspiration