Genetic determinants of host immunity against human rhinovirus infections.
Ian T LambornHelen C SuPublished in: Human genetics (2020)
Human rhinoviruses (RV) are a frequent cause of respiratory tract infections with substantial morbidity and mortality in some patients. Nevertheless, the genetic basis of susceptibility to RV in humans has been relatively understudied. Experimental infections of mice and in vitro infections of human cells have indicated that various pathogen recognition receptors (TLRs, RIG-I, and MDA5) regulate innate immune responses to RV. However, deficiency of MDA5 is the only one among these so far uncovered that confers RV susceptibility in humans. Other work has shown increased RV susceptibility in patients with a polymorphism in CDHR3 that encodes the cellular receptor for RV-C entry. Here, we provide a comprehensive review of the genetic determinants of human RV susceptibility in the context of what is known about RV biology.
Keyphrases
- mycobacterium tuberculosis
- endothelial cells
- immune response
- respiratory tract
- induced pluripotent stem cells
- genome wide
- pluripotent stem cells
- ejection fraction
- end stage renal disease
- copy number
- dna methylation
- prognostic factors
- metabolic syndrome
- skeletal muscle
- inflammatory response
- cell death
- peritoneal dialysis
- binding protein
- smoking cessation