An evaluation of the safety and preliminary efficacy of peri- and post-operative treprostinil in preventing ischemia and reperfusion injury in adult orthotopic liver transplant recipients.

Omar Abdulhameed AlmazrooMohammad Kowser MiahVenkateswaran C PillaiImam Hussain ShaikRuichao XuStalin DharmayanHeather J JohnsonSwaytha GaneshRaymond M PlaninsicAnthony J DemetrisAli Al-KhafajiRoberto LopezMichele MolinariAmit D TevarChristopher HughesAbhinav HumarRaman Venkataramanan

Published in: Clinical transplantation (2021)

Based on this phase 1/2 study, further efficacy studies of treprostinil in preventing I/R injury of liver should be conducted to potentially increase the number of livers available for transplantation.

Keyphrases

pulmonary arterial hypertension
acute myocardial infarction
stem cells
randomized controlled trial
clinical trial
acute ischemic stroke
coronary artery disease
cell therapy
acute coronary syndrome
brain injury
bone marrow
pulmonary hypertension
double blind
placebo controlled