Dysregulated Cyclic Nucleotide Metabolism in Alcohol-Associated Steatohepatitis: Implications for Novel Targeted Therapies.

Diego Montoya-DurangoMary Nancy WalterWalter RodriguezYali WangJulia H CharikerEric C RouchkaClaudio MaldonadoShirish BarveCraig J McClainLeila Gobejishvili

Published in: Biology (2023)

These data strongly implicate dysregulated cAMP and cGMP signaling in the pathogenesis of ASH. Future studies to identify changes in these regulators in a cell-specific manner could lead to the development of novel targeted therapies for ASH.

Keyphrases

municipal solid waste
sewage sludge
single cell
protein kinase
nitric oxide
cell therapy
electronic health record
current status
big data
transcription factor
binding protein
case control
anaerobic digestion
risk assessment
artificial intelligence
liver fibrosis