MUC1-C is a master regulator of MICA/B NKG2D ligand and exosome secretion in human cancer cells.

Yoshihiro MorimotoNami YamashitaTatsuaki DaimonHaruka HiroseShizuka YamanoNaoki HaratakeSatoshi IshikawaAtrayee BhattacharyaAtsushi FushimiRehan AhmadHidekazu TakahashiOlga DashevskyConstantine MitsiadesDonald W Kufe

Published in: Journal for immunotherapy of cancer (2023)

These findings uncover pleotropic mechanisms by which MUC1-C confers evasion of cancer cells to NK cell recognition and destruction.

Keyphrases

nk cells
endothelial cells
induced pluripotent stem cells
transcription factor
pluripotent stem cells