Nailfold capillary abnormalities in childhood-onset systemic lupus erythematosus: a cross-sectional study compared with healthy controls.
Dieneke Schonenberg-MeinemaSandy C BergkampAmara Nassar-Sheikh RashidLeontien B van der AaGodelieve J de BreeRebecca Ten CateMaurizio CutoloA Elisabeth HakPetra Ce Hissink MullerMarieke van OnnaTaco W KuijpersVanessa SmithJ Merlijn van den BergPublished in: Lupus (2021)
Our observations confirm that giants, abnormal capillary morphology and capillary hemorrhages are also observed in cSLE, as was already known for adults with SLE. Number of capillary hemorrhages in cSLE was significantly correlated with disease activity. A high frequency and total amount of "pericapillary extravasations" was observed in cSLE patients, possibly revealing a new subtype of capillary hemorrhage that might reflect endothelial damage in these pediatric patients.
Keyphrases
- systemic lupus erythematosus
- disease activity
- high frequency
- rheumatoid arthritis
- rheumatoid arthritis patients
- ankylosing spondylitis
- transcranial magnetic stimulation
- juvenile idiopathic arthritis
- newly diagnosed
- ejection fraction
- systemic sclerosis
- endothelial cells
- physical activity
- oxidative stress
- patient reported