Caloric restriction remodels the hepatic chromatin landscape and bile acid metabolism by modulating the gut microbiota.

Yun FanHong QianMeijia ZhangChengzhe TaoZhi LiWenkai YanYuna HuangYan ZhangQiaoqiao XuXinru WangPaul A WadeYankai XiaYufeng QinChuncheng Lu

Published in: Genome biology (2023)

These findings suggest that CR-induced microbiota shapes the hepatic epigenome followed by altered expression of genes responsible for bile acid metabolism.

Keyphrases

genome wide
dna methylation
poor prognosis
high glucose
gene expression
diabetic rats
transcription factor
dna damage
signaling pathway
oxidative stress
binding protein
drug induced
long non coding rna
bioinformatics analysis