Effects of early myocardial reperfusion and perfusion on myocardial necrosis/dysfunction and inflammation in patients with ST-segment and non-ST-segment elevation acute coronary syndrome: results from the PLATelet inhibition and patients Outcomes (PLATO) trial.
Gorav BatraHenrik RenlundVijay KunadianStefan K JamesRobert F StoreyP Gabriel StegHugo A KatusRobert A HarringtonC Michael GibsonAndrzej BudajAgneta SiegbahnLars WallentinPublished in: European heart journal. Acute cardiovascular care (2022)
Successful restoration of epicardial blood flow in STEMI was associated with less myocardial necrosis/dysfunction and inflammation. Attainment of normal myocardial perfusion was associated with less myocardial dysfunction in NSTE-ACS.
Keyphrases
- oxidative stress
- acute coronary syndrome
- blood flow
- left ventricular
- end stage renal disease
- percutaneous coronary intervention
- ejection fraction
- chronic kidney disease
- newly diagnosed
- acute myocardial infarction
- clinical trial
- antiplatelet therapy
- peritoneal dialysis
- heart failure
- prognostic factors
- study protocol
- randomized controlled trial
- st elevation myocardial infarction
- magnetic resonance imaging
- patient reported outcomes
- st segment elevation myocardial infarction
- type diabetes
- skeletal muscle
- weight loss
- acute ischemic stroke
- cerebral ischemia