Peroxiredoxin 6 mediates protective function of astrocytes in Aβ proteostasis.
Joanna E PankiewiczJenny R DiazMitchell Martá-ArizaAnita M LizińczykLeor A FrancoMartin J SadowskiPublished in: Molecular neurodegeneration (2020)
We identify here PRDX6 as an important factor regulating response of astrocytes toward Aβ plaques. Demonstration that phagocytic activation of periplaque microglia vary directly with astrocytic PRDX6 expression level implies previously unappreciated astrocyte-guided microglia effect in Aβ proteostasis. Our showing that upregulation of PRDX6 attenuates Aβ pathology may be of therapeutic relevance for AD.