Indoxyl sulfate inhibits muscle cell differentiation via Myf6/MRF4 and MYH2 downregulation.

Stanislas BatailleNathalie McKayLaetitia KoppeAlice BeauBérengère BenoitMarc BartoliNathalie Da SilvaStéphane PoitevinJulien AniortRania ChermitiStéphane BurteyLaetitia Dou

Published in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2023)

In conclusion, IS inhibits Myf6/MRF4 and MYH2 expression during differentiation of muscle cells, which could lead to a defect in myotube structure. Through these new mechanisms, IS could participate in muscle atrophy observed in chronic kidney disease.

Keyphrases

skeletal muscle
induced apoptosis
hypertrophic cardiomyopathy
poor prognosis
cell proliferation
cell cycle arrest
cell death
heart failure
binding protein
left ventricular
endoplasmic reticulum stress
atrial fibrillation
long non coding rna