Induced expression of GINS complex is an essential step for reactivation of quiescent stem-like tumor cells within the peri-necrotic niche in human glioblastoma.

Tokuhiro KimuraDan CuiHiroo KawanoChihiro Yoshitomi-SakamotoNobuyuki TakakuraEiji Ikeda

Published in: Journal of cancer research and clinical oncology (2018)

These findings indicate the essential role of GINS complex in the switch between quiescence and proliferation of tumor cells inside and outside the peri-necrotic niche.

Keyphrases

endothelial cells
high glucose
poor prognosis
signaling pathway
diabetic rats
induced pluripotent stem cells
binding protein
drug induced
oxidative stress