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Brain-derived Neurotropic factor (BDNF) mediates the protective effect of Cucurbita pepo L. on salivary glands of rats exposed to chronic stress evident by structural, biochemical and molecular study.

Hailah M AlmohaimeedEmad A AlbadawiZuhair M MohammedsalehHadel M AlghabbanHanan S SeleemOsama I RamadanNasra Naeim Ayuob
Published in: Journal of applied oral science : revista FOB (2021)
Pumpkin ameliorates the depressive-like status induced in rats following exposure to chronic stress through exerting a promising anti-inflammatory, antioxidant and anti-depressant-like effects. The pumpkin, subsequently, improved stress-induced structural changes in the salivary glands that might be due to up-regulation of BDNF expression in the glands.
Keyphrases
  • stress induced
  • anti inflammatory
  • poor prognosis
  • drug induced
  • white matter
  • high glucose
  • resting state
  • binding protein
  • functional connectivity
  • single molecule
  • blood brain barrier