Cytotoxic T-cell-related gene expression signature predicts improved survival in muscle-invasive urothelial bladder cancer patients after radical cystectomy and adjuvant chemotherapy.
Markus EcksteinPamela StrisselReiner StrickVeronika WeyererRalph WirtzCarolin PfannstielAdrian WullweberFabienne LangePhilipp ErbenRobert StoehrSimone BertzCarol Imanuel GeppertNicole FuhrichHelge TaubertSven WachJohannes BreyerWolfgang OttoMaximilian BurgerChristian BolenzBastian KeckBernd WullichArndt HartmannDanijel Sikicnull nullPublished in: Journal for immunotherapy of cancer (2021)
The gene expression signature of CD3Z, CD8A and CXCL9 can assess the immune status of MIBC and stratify the survival of MIBC patients undergoing surgery and adjuvant platinum-based chemotherapy. Furthermore, the assay can identify patients with immunological hot tumors with particular high expression of PD-L1 potentially suitable for immunotherapy.
Keyphrases
- gene expression
- patients undergoing
- dna methylation
- end stage renal disease
- ejection fraction
- poor prognosis
- minimally invasive
- early stage
- chronic kidney disease
- prognostic factors
- high throughput
- skeletal muscle
- coronary artery bypass
- high grade
- nk cells
- radiation therapy
- squamous cell carcinoma
- coronary artery disease
- surgical site infection
- atrial fibrillation
- drug induced
- muscle invasive bladder cancer