Effect on the Resistome of Dual vs Monotherapy for the Treatment of Neisseria gonorrhoeae : Results From a Randomized Controlled Trial (ResistAZM Trial).

Vanbaelen Thibaut Florence Eric Christophe Van Dijck Achilleas Tsoumanis Jolein Gyonne Elise Laumen Manoharan-Basil Santhini Sheeba Abdellati SaïdTessa De BlockDe Baetselier Irith Van den Bossche Dorien Van Herrewege Yven Rotsaert Anke Chris Richard Kenyon

Published in: Open forum infectious diseases (2023)

We could not demonstrate a significant effect of dual CRO/AZM therapy on the resistome compared with CRO alone, likely due to a high baseline resistance to AZM. Interventions to prevent the emergence of antimicrobial resistance in MSM are needed.

Keyphrases

antimicrobial resistance
combination therapy
men who have sex with men
study protocol
physical activity
open label
phase iii
stem cells
phase ii
randomized controlled trial
hepatitis c virus
cell therapy
antiretroviral therapy