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Clinical applications of microperimetry in RPGR-related retinitis pigmentosa: a review.

Thomas M W BuckleyJasleen Kaur JollyAmandeep Singh JosanLaura J WoodJasmina Cehajic KapetanovicRobert E MacLaren
Published in: Acta ophthalmologica (2021)
Microperimetry, or fundus-tracked perimetry, is a precise static-automated perimetric technique to assess central retinal function. As visual acuity only deteriorates at a late disease stage in RPGR-related retinitis pigmentosa (RP), alternative markers for disease progression are of great utility. Microperimetry assessment has been of critical value as an outcome measure in a recently reported phase I/II gene therapy trial for RPGR-related RP, both in terms of detecting safety and efficacy signals. Here, we performed a review of the literature. We describe the principles of microperimetry before outlining specific parameters that may be useful as outcome measures in clinical trial settings. The current state of structure-function correlations between short-wavelength autofluorescence, optical coherence tomography and adaptive optics in RPGR-related retinitis pigmentosa are also summarized.
Keyphrases
  • clinical trial
  • optical coherence tomography
  • gene therapy
  • diabetic retinopathy
  • randomized controlled trial
  • high throughput
  • phase ii
  • deep learning
  • phase iii
  • single cell