Early alpha-lipoic acid therapy protects from degeneration of the inner retinal layers and vision loss in an experimental autoimmune encephalomyelitis-optic neuritis model.
Michael DietrichNiklas HellingAlexander HillaAnnemarie HeskampAndrea IssbernerThomas HildebrandtZippora KohnePatrick KüryCarsten BerndtOrhan AktasDietmar FischerHans-Peter HartungPhilipp AlbrechtPublished in: Journal of neuroinflammation (2018)
A prophylactic LA treatment is necessary to protect from visual loss and retinal thinning in EAE-ON, suggesting that a clinical ON trial starting therapy after the onset of symptoms may not be successful.