Multi-omics analysis reveals regulators of the response to PDGF-BB treatment in pulmonary artery smooth muscle cells.
Jidong ChenXiaolei CuiZhengjiang QianYanjiao LiKang KangJunle QuLi LiDeming GouPublished in: BMC genomics (2016)
This integrated analysis of PDGF-BB-regulated transcriptome and proteome was performed for the first time in normal PASMCs, which revealed a crosstalk between PDGF signaling and BMPR2/SMADs axis. Further study demonstrated that PDGF-BB-induced miR-376b upregulation mediated the downregulation of BMPR2, which led to expression change of its downstream targets and promoted proliferation of PASMCs.
Keyphrases
- pulmonary artery
- pulmonary arterial hypertension
- smooth muscle
- vascular smooth muscle cells
- growth factor
- pulmonary hypertension
- single cell
- poor prognosis
- coronary artery
- signaling pathway
- recombinant human
- cell proliferation
- transcription factor
- angiotensin ii
- gene expression
- high glucose
- rna seq
- drug induced
- oxidative stress
- diabetic rats
- epithelial mesenchymal transition
- endothelial cells
- replacement therapy