Resveratrol protects against cadmium-induced cerebrum toxicity through modifications of the cytochrome P450 enzyme system in microsomes.

RES initiated the NXRs (especially for AHR and PXR), decreasing the expression of CYP450 genes, changing the content of CYP450, maintaining CYP450 enzyme normal activities, and exerting antagonistic action against the Cd-induced abnormal response of nuclear receptors. These results suggested that the cerebrum toxicity caused by Cd was reduced by pretreatment with RES. This article is protected by copyright. All rights reserved.