Denosumab-related osteonecrosis of the jaw after tooth extraction and the effects of a short drug holiday in cancer patients: a multicenter retrospective study.

Takumi HasegawaN UedaS I YamadaS KatoE IwataS HayashidaY KojimaM ShinoharaI TojoH NakaharaT YamaguchiT KiritaH KuritaY ShibuyaS SoutomeM Akashinull null

Published in: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2021)

These findings suggest that inflamed teeth should be extracted immediately in patients with cancer who are receiving oncologic doses of denosumab. Drug holidays have no significant impact on the risk of DRONJ.

Keyphrases

bone mineral density
giant cell
drug induced
adverse drug
rectal cancer
cross sectional
prostate cancer
radical prostatectomy
clinical trial
emergency department
body composition