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Copper-catalyzed C2 alkenylation of pyridine- N -oxides with alkynes.

Shuxia WangLei SunMinghui GaoQin JiangWeiming HuYaya LiuChuanzhou Tao
Published in: Chemical communications (Cambridge, England) (2022)
A general and expedient method to construct the scaffolds of 2-alkenylpyridines, through copper-catalyzed C2 alkenylation of pyridine- N -oxides with alkynes, has been disclosed. This protocol shows operational simplicity, good functional group compatibility and broad substrate scope.
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