Long non-coding RNA VAL facilitates PKM2 enzymatic activity to promote glycolysis and malignancy of gastric cancer.
Ting DaiXin ZhangXiang ZhouXiaoxia HuXiaodi HuangFeiyue XingHan TianYun LiPublished in: Clinical and translational medicine (2022)
Our study provides an insight into an lncRNA-dependent regulation on the enzymatic activity of PKM2, and suggests a potential of targeting VAL or PKM2 as promising biomarkers in GC diagnosis and treatment.