The role of mGluR5 on the therapeutic effects of ketamine in Wistar rats.

Published in: Psychopharmacology (2024)

These findings suggest that suppressed mGluR5 activity is required for the antidepressant effects of ketamine. Consequently, the antagonism of mGluR5 enhances the antidepressant effectiveness of low dose ketamine, but eliminates its anxiolytic effects.

Keyphrases

low dose
pain management
major depressive disorder
randomized controlled trial
systematic review
high dose
chronic pain