The relationship of neutrophil elastase and proteinase 3 with risk factors, and chronic complications in type 2 diabetes: A Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) sub-study.

Kwok-Leung OngLiang WuAndrzej S JanuszewskiRachel O'ConnellAimin XuRussell S ScottDavid R SullivanKerry-Anne RyeHuating LiRonald Cw MaLiping LiVal GebskiAlicia J JenkinsWeiping JiaAnthony C Keech

Published in: Diabetes & vascular disease research (2021)

In T2DM plasma NE and PR3 levels are associated with vascular risk factors, and total microvascular disease at baseline, but on rigorous analyses were not associated with on-trial complications. Levels were not changed by fenofibrate.

Keyphrases

risk factors
type diabetes
glycemic control
cardiovascular disease
randomized controlled trial
study protocol
clinical trial
phase ii
insulin resistance
phase iii
metabolic syndrome
skeletal muscle
weight loss
drug induced