Liver mitochondrial DNA damage and genetic variability of Cytochrome b - a key component of the respirasome - drive the severity of fatty liver disease.

Carlos Jose PirolaM GaraycoecheaD FlichmanG O CastañoSilvia Sookoian

Published in: Journal of internal medicine (2020)

NASH is associated with genetic alterations of the liver cellular respirasome, including high cytochrome b variation and mtDNA damage, which may result in broad cellular effects.

Keyphrases

oxidative stress
dna damage
copy number
genome wide
mitochondrial dna
dna repair
dna methylation
fatty acid