CD38 expression on gluten-specific T cells is a robust marker of gluten re-exposure in coeliac disease.
Stephanie ZühlkeLouise Fremgaard RisnesShiva Dahal-KoiralaAsbjørn ChristophersenLudvig M SollidKnut Ea LundinPublished in: United European gastroenterology journal (2019)
The optimal time points for monitoring therapy response in CeD after a three-day oral gluten challenge is four hours for plasma IL-2 or six to eight days for the frequency of tetramer + β7 + TEM cells, but both these parameters involved large interindividual differences. In contrast, CD38 expression on tetramer + β7 + TEM cells increased uniformly and irrespectively of the length of gluten challenge, suggesting that this parameter is more suited for monitoring drug efficacy in clinical trials for CeD.
Keyphrases
- celiac disease
- induced apoptosis
- clinical trial
- poor prognosis
- cell cycle arrest
- irritable bowel syndrome
- magnetic resonance
- endoplasmic reticulum stress
- magnetic resonance imaging
- emergency department
- binding protein
- cell death
- oxidative stress
- stem cells
- cell proliferation
- long non coding rna
- mesenchymal stem cells
- electronic health record
- pi k akt
- drug induced
- replacement therapy