Circulating CD200 is increased in the secretory phase of women with endometriosis as is endometrial mRNA, and endometrial stromal cell CD200R1 is increased in spite of reduced mRNA.
Matthew HamiltonVictoria TurpinAnmar AyoubAmir ReihaniJorge ArredondoKjetil AskDavid A ClarkWarren G FosterPublished in: American journal of reproductive immunology (New York, N.Y. : 1989) (2022)
Failure to suppress circulating CD200 levels in the secretory phase had an 87% specificity and 90% sensitivity for endometriosis. CD200 and increased CD200R1 expression may facilitate development of ectopic deposits by suppressing rejection mechanisms.