Cytokeratin 18 cell death assays as biomarkers for quantification of apoptosis and necrosis in COVID-19: a prospective, observational study.

Brandon Michael HenryIsaac CheruiyotStefanie W BenoitFabian Sanchis-GomarGian Luca SalvagnoJustin Benoit

Published in: Journal of clinical pathology (2021)

Necrosis appears to be the main driver of hospitalisation, whereas apoptosis and necrosis appear to drive ICU admission. Elevated levels CK-18 levels are independent predictors of severe disease, and could be useful for risk stratification of COVID-19 patients and in assessment of therapeutic efficacy in early-phase COVID-19 clinical trials.

Keyphrases

cell death
sars cov
cell cycle arrest
coronavirus disease
clinical trial
endoplasmic reticulum stress
oxidative stress
intensive care unit
emergency department
respiratory syndrome coronavirus
pi k akt
randomized controlled trial
acute respiratory distress syndrome
extracorporeal membrane oxygenation