Antitumor effects of co-treatment of resveratrol with antitumor drugs in ER- and HER2-positive breast cancer cells are due to induction of apoptosis and modulation of estrogen receptor expression.

Beatriz Tinoco FranceschiPatrícia Heloise Alves BezerraMaria Regina Torqueti

Published in: Breast cancer (Tokyo, Japan) (2024)

Resveratrol increasead the in vitro cytotoxic effect of conventional therapy in breast cancer cells. However, it was necessary to block resveratrol-induced autophagy to improve the therapeutic response.

Keyphrases

estrogen receptor
cell cycle arrest
positive breast cancer
breast cancer cells
endoplasmic reticulum stress
induced apoptosis
cell death
oxidative stress
poor prognosis
pi k akt
diabetic rats
signaling pathway
high glucose
drug induced
stem cells