GPX8 regulates clear cell renal cell carcinoma tumorigenesis through promoting lipogenesis by NNMT.

Tin Tin Manh NguyenThi Ha NguyenHan Sun KimThien T P DaoYechan MoonMunjun SeoSunmi KangVan-Hieu MaiYong Jin AnCho-Rok JungJin-Mo KimSunghyouk Park

Published in: Journal of experimental & clinical cancer research : CR (2023)

Taken together, our findings unravel the roles of the VHL-independent GPX8-NNMT axis in ccRCC lipid metabolism as related to the phenotypes and growth of ccRCC, which may be targeted for therapeutic purposes.

Keyphrases

cancer therapy
fatty acid
drug delivery