Immune Checkpoint Inhibitor with or without Radiotherapy in Melanoma Patients with Brain Metastases: A Systematic Review and Meta-Analysis.
Pyeong Hwa KimChong Hyun SuhHo Sung KimKyoung Won KimDong Yeong KimEudocia Quant LeeAyal A AizerJeffrey P GuenetteRaymond Y HuangPublished in: Korean journal of radiology (2020)
ICI combination therapy or ICI combined with radiotherapy showed better local efficacy than ICI monotherapy for treating melanoma brain metastasis. The grade 3 or 4 adverse event rate was highest with ICI combination therapy, and the CNS-related grade 3 or 4 event rate was similar. Prospective trials will be necessary to compare the efficacy of ICI combination therapy and ICI combined with radiotherapy.