SIRT5 functions as a tumor suppressor in renal cell carcinoma by reversing the Warburg effect.

Liu YihanWang XiaojingLiu AoZhang ChuanjieWang HaofeiShen YanHongchao He

Published in: Journal of translational medicine (2021)

Downregulated SIRT5 expression in ccRCC accelerated the Warburg effect through PDHA1 hypersuccinylation and induced tumorigenesis and progression, indicating that SIRT5 may become a potential target for ccRCC therapy.

Keyphrases

renal cell carcinoma
oxidative stress
ischemia reperfusion injury
poor prognosis
high glucose
bone marrow
mesenchymal stem cells
cell therapy
human health
replacement therapy