Topical Versus Intravenous Tranexamic Acid in Patients Undergoing Cardiac Surgery: The DEPOSITION Randomized Controlled Trial.

Andre LamyDmitry A SirotaFrederic JacquesAhmad PoostizadehNicolas NoiseuxSergey EfremovPhilippe DemersBoris AkselrodChew Yin WangRakesh C AroraPiotr BrannyShay P McGuinnessCraig D BrownHugues JeanmartQiang Zhao Haibo Zhang Emilie P Belley-Côté Richard P WhitlockAustin BrowneIngrid CoplandJessica VincentRutaba KhatunKumar BalasubramanianShrikant Ishver BangdiwalaMichael H McGillionAlison E Fox-RobichaudJessica SpenceSalim Yusuf Philip J Devereauxnull null

Published in: Circulation (2024)

Among patients having cardiac surgery, topical administration of tranexamic acid resulted in an 8.3% absolute increase in transfusion without reducing the incidence of seizure, compared to intravenous tranexamic acid.

Keyphrases

cardiac surgery
randomized controlled trial
acute kidney injury
patients undergoing
high dose
wound healing
study protocol
risk factors
clinical trial