A method for estimating coherence of molecular mechanisms in major human disease and traits.

Mikhail G DozmorovKellen G CresswellSilviu-Alin BacanuCarl CraverMark ReimersKenneth S Kendler

Published in: BMC bioinformatics (2020)

We present a general-purpose method for estimating and comparing the coherence of molecular-interaction gene networks that accounts for the network size and shape differences. Our results highlight gaps in our current knowledge of genetics and molecular mechanisms of complex phenotypes and suggest priorities for future GWASs.

Keyphrases

genome wide
endothelial cells
healthcare
induced pluripotent stem cells
copy number
current status
pluripotent stem cells
dna methylation
gene expression
genome wide identification