Tumor Necrosis Factor-α Regulates the TRPA1 Expression in Human Odontoblast-Like Cells.

Our study demonstrated that TRPA1 expression in HOD-like cells was evidently upregulated by TNF-α, presumably via TNFR1. TNF-α induced significant increasement in the intracellular distributions of TRPA1 proteins, with increases in the cytoplasm, ER membrane, and mitochondria, to actively participate in noxious external stimuli perception and transduction of hyperalgesia.