Weight loss induced increase in fasting ghrelin concentration is a predictor of weight regain: evidence from the Diabetes Remission Clinical Trial.
George ThomAlasdair McIntoshClaudia-Martina MessowWilma S LeslieAlison C BarnesNaomi T BrosnahanLouise McCombieDalia MalkovaAhmad Al-MrabehSviatlana ZhyzhneuskayaPaul WelshNaveed SattarRoy TaylorMichael Ej LeanPublished in: Diabetes, obesity & metabolism (2020)
The rise in ghrelin (but not any other measured hormone) during diet-induced weight-loss was a predictor of weight regain during follow-up, and concentrations remained elevated over time, suggesting a small but significant compensatory drive to regain weight. Attenuating the effects of ghrelin may improve WLM. This article is protected by copyright. All rights reserved.
Keyphrases
- weight loss
- gastric bypass
- bariatric surgery
- roux en y gastric bypass
- glycemic control
- clinical trial
- weight gain
- type diabetes
- obese patients
- cardiovascular disease
- blood glucose
- body mass index
- high glucose
- physical activity
- growth hormone
- randomized controlled trial
- blood pressure
- disease activity
- drug induced
- diabetic rats
- double blind
- systemic lupus erythematosus
- skeletal muscle